spot_img
Top StoriesWhat Is Tromethamine, or Tris? It Helps Stabilize Covid...

What Is Tromethamine, or Tris? It Helps Stabilize Covid Vaccines

-

- Advertisment -


When the Food and Drug Administration authorized the emergency use of the Pfizer-BioNTech vaccine in children ages 5 to 11 last month, the agency noted that the pediatric version would be a bit different than the one for adults: a third the size, with a different buffer for added stability.

The news set off a wave of disinformation on social media about the new ingredient: Tris, or tromethamine.

The ingredient, however, has a time-tested track record of safety. It is “a commonly used buffer in a variety of other F.D.A.-approved vaccines and other biologics, including products for use in children,” the agency said in its statement announcing the authorization for Pfizer’s pediatric doses.

Such buffers “help maintain a vaccine’s pH (a measure of how acidic or alkaline a solution is) and stability,” according to the F.D.A., which says that the new formulation gives vaccine providers more flexibility in storage.

Pfizer’s pediatric dose also removes extra salt — sodium chloride and potassium chloride — according to Dr. Sandra Fryhofer, the American Medical Association’s liaison to a Centers for Disease Control and Prevention immunization committee. Taken together with the “tris buffer,” she said in an A.M.A. interview, the changes “make the vaccine product more stable at regular refrigerator temperatures for longer periods of time. The kid version vials can be stored unopened in regular refrigerators for up to 10 weeks.”

The ingredient is not specific to Pfizer’s pediatric Covid vaccine doses. Kit Longley, a Pfizer spokesman, said in an email on Saturday that the compound was being used in adult doses as of this month, and that the manufacturing and ingredient list were otherwise unchanged. Tromethamine is also used in Moderna’s Covid vaccine.



Source link

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Health

US delegation to head to Vienna for indirect Iran nuclear talks | Nuclear Energy News

The Biden administration still believes revival of nuclear deal is ‘viable option’, State Department spokesman says.The United States...

Elizabeth Holmes’ defense rests its case

While the prosecution called 29 witnesses to testify, the defense's case relied almost entirely on Holmes. During her...

The Coronavirus Attacks Fat Tissue, Scientists Find

From the start of the pandemic, the coronavirus seemed to target people carrying extra pounds. Patients who were...

The Era of the Celebrity Meal

On a Friday afternoon in the spring of 2020, Hope Bagozzi, the chief marketing officer at the Canadian...
- Advertisement -

Must read

US delegation to head to Vienna for indirect Iran nuclear talks | Nuclear Energy News

The Biden administration still believes revival of nuclear...

Elizabeth Holmes’ defense rests its case

While the prosecution called 29 witnesses to testify,...

You might also likeRELATED
Recommended to you