A search-and-rescue operation has been launched by the Taiwanese air force to find the jet.
The jet took off from the Chiayi Air Base at 2.55pm (06:55GMT] and disappeared from radars at 3.23pm, reported Focus Taiwan citing the country’s military.
A response centre has also been set up to monitor the search and rescue operation.
Taiwan received F-16s from the US, which is the island nation’s main arms supplier. Last year, Taiwan had commissioned the US government’s defence contractor Lockheed Martin last year to upgrade its ageing fleet of F-16s to more advanced F-16Vs, reported Sputnik.